Protein Details: Acid-sensing ion channel 4-A

Protein ID

ICDB_Pro_1130

Protein Name

Acid-sensing ion channel 4-A

Gene Name

asic4a; accn4a

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Length

539 amino acids

AlphaFoldDB

AF-Q708S4-F1-model_v4.pdb

Function

Cation channel with high affinity for sodium; which is gated by extracellular protons and inhibited by the diuretic amiloride.

Sequence

MPIEFVCKIKFAEEDEKQKGNQDGDKESLIEESCSPPTKDLAGFASASSLHGINHIFVSGRLGVRQTLWALAFLVSLALFLYQAAKCAISYLEHPHVTALNEEATPEMVFPAVTICNINRFRFSALTDADIYHLANLTGLPPKNKDGHKPTDLEYPAPDMQDIFNRTGHQLEEMLKSCNFSGQNCSAEDFTVVYTRYGKCYTFNGNKTTSRKTKQGGMGNGLEIMLDIQQDDYLPIWKETNETSLEAGIRVQIHSQDEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRSTSEQMIPGYDTYSISACRLRCETLEVLRECKCRMVHMPGDANICTPSDIKCVDKALALLQKSSGDTCFCETPCNLTRYGKELSMVKIPSKGSARYLSRKYDKSEDYIRDNFLVLDIFFEALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASVLTILEILDYVYEVIKHRLERLLRPQRDDKKQTQQQQQASTVATVNLEEMKAKDSSEMSRSHSEGAYANTILPNHHHHHRTHHRVSEDFAC

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in central nervous system

DOI ID

10.1074/jbc.m401477200

RefSeq

NP_999952.1